What is myoinositol?
Myoinositol (MI) is a form of inositol, which is a member of the B vitamin
complex. MI is naturally found in foods including whole grains, beans,
nuts and fruit. Myoinositol is also available in supplement form. In the
body, MI performs several important functions related to cellular communication,
particularly in response to hormones.
Why Myoinositol for fertility?
For PCOS: Decades of research support the role of MI in improving cells’ sensitivity
to the hormone insulin. Specifically, in women with Polycystic Ovarian
Syndrome (PCOS), treatment with MI has been shown to lower circulating
insulin levels, reduce symptoms of hyperandrogenism (acne and excess hair
growth), and promote ovulation.
For Poor Responders: Interestingly, research conducted looking at the impact of MI supplementation
in women with PCOS undergoing IVF revealed that women who took MI prior
to IVF had better egg and embryo quality, and were less likely to experience
The encouraging findings in women with PCOS have prompted researchers to
take a closer look at MI in non-PCOS populations. Low levels of MI in
the follicular fluid is associated with poor egg quality. At the level
of ovary tissue specifically, scientists believe MI may play a critical
role in FSH (follicle stimulating hormone) signaling, which drives egg
maturation. Several studies show that poor responders pre-treated with
MI prior to IVF demonstrate improved sensitivity to ovarian stimulation drugs.
Bottom Line: Clinical Use of Myoinositol:
Supplementation with MI is becoming part of clinical practice for both
women with Polycystic Ovarian Syndrome (PCOS) and IVF poor responders.
At Pulling Down the Moon we recommend myoinositol supplementation for
three months prior to ART cycles for women with PCOS, poor responders
and/or unexplained infertility.
Caprio et al. Journal of Ovarian Research (2015) 8:37.
Lagana et al. Metabolism and Ovarian Function in PCOS Women: A Therapeutic
Approach with Inositols. International Journal of Endocrinology. Volume 2016,