Understanding the Link Between Myoinositol and Fertility

What is myoinositol?

Myoinositol (MI) is a form of inositol, which is a member of the B vitamin complex. MI is naturally found in foods including whole grains, beans, nuts and fruit. Myoinositol is also available in supplement form. In the body, MI performs several important functions related to cellular communication, particularly in response to hormones.

Why Myoinositol for fertility?

For PCOS: Decades of research support the role of MI in improving cells’ sensitivity to the hormone insulin. Specifically, in women with Polycystic Ovarian Syndrome (PCOS), treatment with MI has been shown to lower circulating insulin levels, reduce symptoms of hyperandrogenism (acne and excess hair growth), and promote ovulation.

For Poor Responders: Interestingly, research conducted looking at the impact of MI supplementation in women with PCOS undergoing IVF revealed that women who took MI prior to IVF had better egg and embryo quality, and were less likely to experience ovarian hyperstimulation.

The encouraging findings in women with PCOS have prompted researchers to take a closer look at MI in non-PCOS populations. Low levels of MI in the follicular fluid is associated with poor egg quality. At the level of ovary tissue specifically, scientists believe MI may play a critical role in FSH (follicle stimulating hormone) signaling, which drives egg maturation. Several studies show that poor responders pre-treated with MI prior to IVF demonstrate improved sensitivity to ovarian stimulation drugs.

Bottom Line: Clinical Use of Myoinositol:

Supplementation with MI is becoming part of clinical practice for both women with Polycystic Ovarian Syndrome (PCOS) and IVF poor responders. At Pulling Down the Moon we recommend myoinositol supplementation for three months prior to ART cycles for women with PCOS, poor responders and/or unexplained infertility.

Sources:

Caprio et al. Journal of Ovarian Research (2015) 8:37.

Lagana et al. Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols. International Journal of Endocrinology. Volume 2016,

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