• PCOS and Coenzyme Q10 Supplementation

    By Robin Miller, RDN

    Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women, affecting up to 10% of women of childbearing age. Despite what the name suggests, it is actually a disorder of the endocrine system–think hormones! You can even be diagnosed with PCOS even without having ovarian cysts. 

    PCOS is characterized by high levels of androgens (“male” hormones), including testosterone, androstenedione, dihydrotestosterone (DHT), dehydroepiandrosteron (DHEA) and DHEA sulfate (DHEA-S). Higher than normal levels of insulin are also common due to to insulin resistance (much like that seen in type 2 diabetes) over time. When you have insulin resistance, your insulin isn’t working as well as it should to signal for glucose to be transported out of the blood and into the cells of the body to be used for energy. To compensate, the pancreas produces more insulin leading to high insulin levels, which seem to drive the higher testosterone levels in PCOS.

    A recent study suggests that supplementation of Coenzyme Q10 (CoQ10), has beneficial effects on glucose metabolism as well as serum total and LDL cholesterol levels in people with PCOS. In this study subjects took 100 mg of CoQ10 daily for a 12-week period at the conclusion of the study a notable improvement in overall fasting glucose, insulin resistance, and total and LDL cholesterol was observed in subjects. 

    So, what is Coezyme Q10?  Coenzyme Q10 (CoQ10) is a nutrient that occurs naturally in the body. CoQ10 is also in many foods we eat. CoQ10 is involved in energy production and acts as an antioxidant, which protects cells from damage and plays an important part in the metabolism.  

    Unfortunately, as we age, naturally occurring levels of CoQ10 in our body decline. Evidence suggests that supplementing CoQ10 may help many different conditions such as high blood pressure and heart failure and most recently PCOS. 

    Want to learn more about how supplements can help you? Schedule a  nutrition consult and work with one of our Registered Dietitians to develop an individualized supplement and treatment plan specifically designed for you!

  • CoQ10 Improves Egg and Embryo Quality

     

    By Margaret Eich, MS, RDN

    An exciting new study shows promising results for CoQ10 supplementation in women with poor ovarian reserve doing IVF. In the study, 186 women under age 35 with poor ovarian reserve, defined as Anti-Müllerian hormone (AMH) < 1.2 ng/mL, and antral follicle count (AFC) < 5, were randomized to receive either treatment with 600 mg CoQ10 (200 mg 3 times per day) or control (no treatment) for 60 days leading up to their IVF cycle.

    The results were pretty striking. The CoQ10 group had significantly more high quality day 3 embryos (1 vs. 0 in the control group), significantly less gonadotropins needed for stimulation, significantly more eggs retrieved (4 vs. 2 in the control group), and significantly higher fertilization rate (67% vs. 45% in the control group). In addition, significantly more patients who took CoQ10 had embryos to freeze (18.4% vs. 4.3% in the control group). The CoQ10 group also had higher pregnancy rates (32% vs. 17% in the control group) and higher live birth rates (29% vs. 16% in the control group), but these results were not statistically significant.

    CoQ10 is an antioxidant and plays an essential in energy production in our body cells, including maturing eggs. CoQ10 is thought to exert its beneficial effects by neutralizing free radicals that could damage the DNA or other structures within the egg. Damage to DNA can prevent fertilization or result in a nonviable embryo. In addition, because of CoQ10’s role in energy production, CoQ10 likely also supports the energy needs of maturing eggs, thus leading to better quality eggs and embryos.  CoQ10 tends to be a safe and well-tolerated supplement, and in this study, there were no adverse effects reports from supplementing with CoQ10.

    Absorption of CoQ10 is best when the dose is divided into 3 doses with meals during the day. Because CoQ10 is fat-soluble, having fat with CoQ10 increases the absorption. Learn more about our CoQ10 supplement here.  

    Reference: Xu Y, Nisenblat V, Cuiling L, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive Biology and Endocrinology. 2018;16:29.

    **Save 25% off CoQ10 in June with the promo code EGG25! Available in-center and online while supplies last.