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Research Round-Up: Myoinositol

by Beth Heller, MS

If you are trying to conceive, your OB Gyn or Reproductive Endocrinologist may have recommended you begin supplementation with myoinositol.   Myoinositol is compound that belongs to the B Vitamin complex and plays a role in cell growth and maturation as well as insulin metabolism.  Much of the research into the role of myoinositol in reproduction has been done in patients with Polycystic Ovarian Syndrome (PCOS), where administration of this supplement has been shown to improve blood sugar regulation, restore menstrual cyclicity, and manage PCOS symptoms like acne and hirsutism and even increase conception rates.  When myoinositol was given to women with PCOS undergoing IVF, researchers also noted these women had fewer degenerated oocytes and a greater number of mature eggs (1,2).  Because of these findings researchers have moved beyond the PCOS population to explore whether myoinositol has the ability to improve egg and embryo quality in a more general population.

Here is a round-up of some of the recent findings:

  • Non-PCOS women pre-treated with myoinositol required a lower dose of ovarian-stimulating hormones  during IVF and showed a trend toward greater implantation rates (3)
  • PCOS patients undergoing IVF treated with myoinositol had more mature oocytes and fewer immature follicles (4)
  • Non-PCOS treated with a combination of myoinositol and melatonin after a failed IVF cycle showed  greater amounts of mature oocytes, better embryo quality and higher pregnancy rates (5)

If you are interested in learning more about the way that diet can support fertility you can schedule an appointment with a Pulling Down the Moon nutrition specialist.   Please note that you should always speak to your physician before starting any nutrition supplement regimen.   


1. Papeleo et al.  Fertility and Sterility Vol. 91, No. 5, May 2009

2. Papeleo et al. European Journal of Obstetrics & Gynecology and Reproductive Biology Vol. 147, 2009.

3. Lisi et al. Reprod Biol Endocrinol. 2012 Jul 23;10:52

4. Ciotta et al. Eur Rev Med Pharmacol Sci. 2011 May;15(5):509-14

5.  Unfer et al. Gynecological Endocrinology, 2011; Early Online, 1-5