Myo-inositol for Male Fertility?

By Margaret Eich, MS, RDN

Myo-inositol is a supplement that we often recommend for lowering insulin and testosterone levels and promoting cycle regularity in women with polycystic ovarian syndrome (PCOS). We also recommend it for egg quality. Now evidence is mounting that myo-inositol may have a beneficial effect for sperm quality in men as well!

Myo-inositol is a molecule that your body makes from glucose. Myo-inositol is also found in foods in foods like fruits, beans, grains, and nuts. It has half the sweetness of glucose, thus if you mix myo-inositol powder into some water, you will taste a slight sweetness. Myo-inositol is critical for cell growth, cell membrane formation, lipid synthesis, and cell signaling in your body.

According to the research, myo-inositol seems to have a beneficial impact on mitochondrial function. If you remember from high school biology, the mitochrondria are the “powerhouse of the cell,” meaning they are responsible for energy production. The idea is that supporting the mitochondria helps ensure the sperm have adequate energy production to support proper motility. In the research, incubation of sperm from men with low sperm count, motility, and/or morphology with myo-inositol resulted in higher sperm motility. Myo-inositol may also have antioxidant effects.

A recent study of 100 men with low sperm count and/or low sperm motility looked at supplementation with myo-inositol, alpha-lipoic acid, folic acid, betaine, thiamine, and vitamins B6 and B12 to determine the impact on sperm quality. After a 90-day treatment period, there was a significant increase in sperm concentration, progressive motility, total motile sperm count, and normal sperm morphology. Within 6 months of discontinuing the supplements, the partner became pregnant in 40 cases either naturally or via IUI of IVF. No adverse effects were reported in the 100 men following this supplement regimen for 90 days.

This study has really striking results. Because multiple nutrients were used, we can’t be sure how much of the impact is due to myo-inositol compared to other nutrients. It would also be great to see a placebo-controlled trial with myo-inositol. For now, these results are looking promising for using myo-inositol to improve sperm motility in men with subfertility of unknown cause. Stay tuned as we learn more about this important topic! 

References:

  1. Canepa P, Dal Lago A, De Leo C. Combined treatment with myo-inositol, alpha-lipoic acid, folic acid, and vitamins significantly improves sperm parameters of sub-fertile men: a multi-centric study. Eur Rev Med Pharmacol Sci. 2018;22:7078-7085.
  2. Condorelli RA, et al. Myo-inositol as a male fertility molecule. Eur Rev Med Pharmacol Sci. 2017; 21(2 Suppl): 30-35.

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